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Alzheimer's Disease
Genes Affecting Alzheimer's Disease
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Here is an extract from the ebook "The Complete Guide to Treating & Coping with
Alzheimer's Disease"
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Genetics of Alzheimer's Disease
Genes play a prominent role in Alzheimer’s disease, although the actual extent of their
effect is still debated. It is evident that genes control and determine the color of eyes, hair
and other traits in all living beings. However, genes do not function by themselves; they
receive active help from other environmental characteristics. Genes depend on various
physical and chemical features of their surroundings to give final shape to those traits.
Genes are present within the nucleus of every cell and build up a new protein with other
molecules. The new protein should contain specific and appropriate DNA (deoxyribonucleic
acid). Mutations in DNA could result in defective proteins, which might disable your body
and cell functions. This may later lead to various irregularities and cause diseases, leading
to death.
So, you might attribute Alzheimer’s disease to gene mutations. Most other gene disorders
and diseases are due to irregularities in a single gene but Alzheimer’s disease may occur
due to multiple gene disorders, not the work of any single gene. Multiple gene mutations,
multiple chromosomes and defective genes of both parents could be part of the cause of
Alzheimer’s disease.
Genes Affecting Alzheimer's Disease
Sporadic and Familial are two basic types of genes that are believed to cause Alzheimer’s
disease.
Familial Alzheimer’s disease (FAD) refers to family inheritance of a gene causing this disease.
One parent with such a defective gene could pass it to their offspring. All children have a
fifty percent chance of acquiring Alzheimer’s disease in later years. This inheritance is called
‘autosomal dominant’. In such cases, mutations occur on chromosomes 1, 14, and 21.
Familial Alzheimer’s disease affects people below sixty years of age.
Sporadic Alzheimer's Disease occurs more commonly than Familial Alzheimer’s disease
(FAD). It affects persons above sixty years old. The Sporadic form is due to presence of
the ApoE gene on chromosome 19. ApoE is present in many different forms; genes of
apoE2, apoE3, or apoE4 occur frequently. You may inherit any one of them from each of
your parents. Some people could even receive two of them. There is no conclusive proof to
show which of these carry the higher risk of Alzheimer’s disease. Most affected patients
carry two apoE4.
Nevertheless, some people that are carrying two apoE4 do not contract Alzheimer’s
disease at all.
How to Detect ApoE
Blood tests can help in determining the presence of apolipoprotein (apoE) in your genes.
However, they cannot indicate whether you have Alzheimer’s or if you may or may not
acquire Alzheimer’s disease later in life.
Currently, there is no accurate test to indicate whether apoE could cause the disease. ApoE
testing may expose confidential information about different patients. Therefore, such
testing is normally reserved for genuine Alzheimer’s disease patients only. You may take
this test if you have many other positive indicators for Alzheimer’s disease.
Genetic counseling, before and after apoE testing, is helpful to patients and their family
members.
It helps them to deal with this crisis in their lives while they suffer severe distress and
depression with extensive emotional strain due to Alzheimer’s disease. However, apoE
testing alone cannot confirm the risk of Alzheimer’s disease. A combination of many
different factors like neurological, family history, and other irregularities in behavioral and
functional abilities are needed for best diagnosis and plan for treatment and support. Only
after that, can doctors discuss the existence of Alzheimer’s disease in any particular
individual.
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You like the above extract from the ebook "The Complete Guide to Treating & Coping
with Alzheimer's Disease"? Then, read on...
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It's a good bet that you, like the rest of us, have forgotten something and then, jokingly,
said, "it must be old-timers disease."
We didn't mean to be hurtful, but our comment can cut deeply if there is a person present
who is trying to cope with the disease.
With more than 18 million known cases of Alzheimer's Disease world-wide, the odds are
that you have had some contact with someone who is close to this horrible degenerating
disease. It may be a victim or a family member of a victim.
Maybe you even suspect that a loved one is exhibiting early stage symptoms of Dementia
and/or Alzheimer's Disease. If you think that may be the case, The Complete Guide to
Treating & Coping with Alzheimer's Disease is just what you need.
Learning what you need to know to understand the disease gives you a definite roadmap
for how to cope, not only with the disease but with caring for your loved one.
Alzheimer's Disease is actually a form of dementia. What comes first - dementia or
Alzheimer's? There are many conditions being investigated as possible causes of
Alzheimer's Disease.
We are still exploring the possible causes of Alzheimer's Disease.
This disease affects vital areas of the patient's brain with serious effects on those parts
which control long-term memory, motion, reasoning and thought.
If you suspect that a friend or family member is suffering from Alzheimer's, early detection
is critical.
No matter what your situation is, you will find the answers you need right here:
Need to identify the symptoms?. . .Chapter 5 breaks it down for you into the three types
of symptoms: early, developing and serious
There are 10 early warning signs and you can learn more about them in Chapter 6
Chapter 7 outlines the different stages of Alzheimer's Disease
Did you know that estrogen plays a role for women in regards to this disease? Chapter 10
explains it for you.
Discover how important early signs can be in Chapter 11.
Do you need to learn better ways to communicate with an Alzheimer's patient? Chapter 26
teaches you how to do that effectively.
How to care for an Alzheimer's patient without sacrificing your own health can be learned in
Chapter 31.
Does your friend or family member exhibit signs of uncertainty when attempting simple,
routine tasks? Are behavioral patterns escalating to borderline violence? Is there a family
history of dementia or Alzheimer's Disease?
Any or all of the above could just be normal signs of aging. However, why take the risk?
Don't wait until it's too late.
Get the answers you need now!
Remember, early detection is critical to diagnosing and managing this debilitating
disease. Don't bet a life on it. Grab your copy now!
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Brought to you by Jacob Gan, PhD (Michigan)
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